Drug Class And Mechanism: Atomoxetine is an oral drug that is used for
treating attention deficit hyperactivity disorder (ADHD). An estimated 15
million Americans have ADHD, and approximately half will require drug
therapy to control symptoms. While some children outgrow ADHD, about 60%
continue to have symptoms into adulthood. Until recently, drug therapy has
consisted almost exclusively of stimulants such as amphetamines and
methylphenidate (Ritalin and others). These stimulants are restricted in
availability under the Controlled Substances Act because of their
potential for abuse. Atomoxetine is the first drug for ADHD that is not a
stimulant under the Controlled Substances Act.
Although it is not known precisely how atomoxetine reduces the symptoms of
ADHD, scientists believe it works by affecting neurotransmitters in the
brain, chemicals that the nerves use for communicating with one another.
One neurotransmitter, norepinephrine, is considered important in
regulating attention, impulsivity and activity levels, all of which are
abnormal in ADHD. Norepinephrine is manufactured by nerves in the brain
and then is released from the nerves. The norepinephrine travels to other
nerves and attaches to the nerves, causing changes in the way the nerves
function. Some of the norepinephrine that is released is reabsorbed by the
nerves that produce it thereby reducing the amount of epinephrine that is
available to travel to other nerves. Atomoxetine is believed to reduce the
reabsorption of epinephrine by nerves. This makes more norepinephrine
available to attach to other nerves in the brain. Atomoxetine was approved
by the FDA November, 2002.
Dosing: Atomoxetine is taken once or twice daily. It may be taken with or
without food. The capsules should never be broken and sprinkled on food.
They must be taken whole.
Prescribed For: Atomoxetine is used for the treatment of ADHD in children,
adolescents and adults.
Storage: Atomoxetine capsules should be stored at room temperature,
59-86°F (15-30 °C).
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